Friday, February 24, 2012
The actions of bismuth in the treatment of Helicobacter pylori infections: an update.
The actions of bismuth in the treatment of Helicobacter pylori infections: an update.
Feb 2012
Source
Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol and The Laboratory of Integrative Biosciences, College of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China. gerg@mail.sysu.edu.cn.
Abstract
Helicobacter pylori causes various gastric diseases, such as gastritis, peptic ulcerations and gastric cancer. Bismuth-based triple or quadruple therapies have been commonly recommended for the treatment of H. pylori infections. Up to now, the molecular mechanisms by which bismuth inhibits the growth of H. pylori are far from clear. The present concise review intends to cover the most recent reports and discoveries in the field of the inhibitory mechanism of bismuth against H. pylori as well as the bacterial protective response to drug treatment, which will help us to further understand the molecular mechanisms underlying the actions of metal-based drugs and stimulate further development of effective anti-bacterial drugs.
Labels: anti-bacterial drugs, gastric diseases, gastritis, Helicobacter pylori, peptic ulcerations gastric cancer
# posted by Pat O'Connor @ 7:15 AM 
