Monday, August 27, 2012
Extensive in vivo resilience of persistent salmonella.
2012
Source
Focal Area Infection Biology, Biozentrum, University of Basel, Basel, Switzerland.
Abstract
Chronic infections caused by persistent pathogens represent an important health problem. Here, we establish a simple practical mouse Salmonella infection model for identifying bacterial maintenance functions that are essential for persistency. In this model, a substantial fraction of Salmonella survived even several days of treatment with a potent fluoroquinolone antibiotic indicating stringency of the model. Evaluation of twelve metabolic defects revealed dramatically different requirements for Salmonella during persistency as compared to acute infections. Disrupted synthesis of unsaturated/cyclopropane fatty acids was the only defect that resulted in rapid Salmonella clearance suggesting that this pathway might contain suitable targets for antimicrobial chemotherapy of chronic infection.
Full Text Article
Labels: antimicrobial chemotherapy, chronic infection, fatty acids, fluoroquinolone, pathogen, salmonella
# posted by Pat O'Connor @ 10:10 AM 
